A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid

Rapid advancements in traditional bone tissue engineering have led to innovation repair models and the resolution of insurmountable clinical issues like graft scarcity. The pathophysiological process treating disease, however, is a multidimensional multimodal regenerative regulatory mechanism that includes numerous immune, inflammatory, or metabolic responses related organism itself. Based on 3D vitro cell culture system remarkably identical body's tissue, organoid biomimicking organ environment. It can accurately mimic actual regeneration condition vivo because it shares same physiological function, structure, morphology, as endogenous tissue. As disruptive medicine technology, has wide application prospects fields development, gene editing, disease modeling, precision therapy. Herein, development basis different cell-based organoids are reviewed, current status materials, cells, construction methods for building described, challenges future medical discussed.